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1974 4
1975 6
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1977 4
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1986 6
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1995 21
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2002 73
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2005 119
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2007 132
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5,795 results

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Natural products of pentacyclic triterpenoids: from discovery to heterologous biosynthesis.
Li Y, Wang J, Li L, Song W, Li M, Hua X, Wang Y, Yuan J, Xue Z. Li Y, et al. Nat Prod Rep. 2023 Aug 16;40(8):1303-1353. doi: 10.1039/d2np00063f. Nat Prod Rep. 2023. PMID: 36454108 Review.
The rapid development of synthetic biology, metabolic engineering, and fermentation technology has broadened channels for the accumulation of pentacyclic triterpenoid saponins. In this review, we summarize the classification, distribution, structural characteristics, and b …
The rapid development of synthetic biology, metabolic engineering, and fermentation technology has broadened channels for the accumulation o …
Pentacyclic triterpenes: New tools to fight metabolic syndrome.
Sharma H, Kumar P, Deshmukh RR, Bishayee A, Kumar S. Sharma H, et al. Phytomedicine. 2018 Nov 15;50:166-177. doi: 10.1016/j.phymed.2018.09.011. Epub 2018 Sep 5. Phytomedicine. 2018. PMID: 30466975 Review.
These factors are tied to the increased risk for type-II diabetes and cardiovascular diseases including myocardial infarction in patients with metabolic syndrome. PURPOSE: To review the proposed molecular mechanisms of pentacyclic triterpenes for their potential use in the …
These factors are tied to the increased risk for type-II diabetes and cardiovascular diseases including myocardial infarction in patients wi …
Pentacyclic Triterpene Bioavailability: An Overview of In Vitro and In Vivo Studies.
J C Furtado NA, Pirson L, Edelberg H, M Miranda L, Loira-Pastoriza C, Preat V, Larondelle Y, André CM. J C Furtado NA, et al. Molecules. 2017 Mar 4;22(3):400. doi: 10.3390/molecules22030400. Molecules. 2017. PMID: 28273859 Free PMC article. Review.
Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of the human diet. ...As plant matrices play a critical role in triterpene bioaccessibility, this review covers literature data on the bioavaila …
Pentacyclic triterpenes are naturally found in a great variety of fruits, vegetables and medicinal plants and are therefore part of t …
Natural pentacyclic triterpenoid acids potentially useful as biocompatible nanocarriers.
Malík M, Velechovský J, Tlustoš P. Malík M, et al. Fitoterapia. 2021 Jun;151:104845. doi: 10.1016/j.fitote.2021.104845. Epub 2021 Mar 5. Fitoterapia. 2021. PMID: 33684460 Review.
This review focuses on the supramolecular properties of triterpenoid acids with regard to their subsequent use as biocompatible nanocarriers. The review also considers the current list of pentacyclic triterpene acids for which molecular self-assembly has been confirmed wit …
This review focuses on the supramolecular properties of triterpenoid acids with regard to their subsequent use as biocompatible nanocarriers …
Role of Pentacyclic Triterpenoid Acids in the Treatment of Bladder Cancer.
Ghosh A, Panda CK. Ghosh A, et al. Mini Rev Med Chem. 2022;22(9):1331-1340. doi: 10.2174/1389557521666211022145052. Mini Rev Med Chem. 2022. PMID: 34719363 Review.
Bladder cancer carries a poor prognosis and has proven resistance to chemotherapy. Pentacyclic Triterpenoid Acids (PTAs) are natural bioactive compounds that have a well-known impact on cancer research because of their cytotoxic and chemopreventive activities. ...Specific …
Bladder cancer carries a poor prognosis and has proven resistance to chemotherapy. Pentacyclic Triterpenoid Acids (PTAs) are natural …
Antiurolithiatic effects of pentacyclic triterpenes: The distance traveled from therapeutic aspects.
Lobine D, Ahmed S, Aschner M, Khan H, Mirzaei H, Mahomoodally MF. Lobine D, et al. Drug Dev Res. 2020 Sep;81(6):671-684. doi: 10.1002/ddr.21670. Epub 2020 Apr 20. Drug Dev Res. 2020. PMID: 32314397 Review.
Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triterpenes represent a group of naturally occurring compounds which holds immense potential as therapeutic for treating kidney stone. ...It is an …
Standard treatments are available both to avert and treat urolithiasis, but with significant adverse side effects. Pentacyclic triter …
Nanoformulations for Delivery of Pentacyclic Triterpenoids in Anticancer Therapies.
Kaps A, Gwiazdoń P, Chodurek E. Kaps A, et al. Molecules. 2021 Mar 21;26(6):1764. doi: 10.3390/molecules26061764. Molecules. 2021. PMID: 33801096 Free PMC article. Review.
Among the known natural triterpenoids, we can distinguish lupane-, oleanane-, and ursane-types. Pentacyclic triterpenoids are known to have many biological activities, e.g., anti-inflammatory, antibacterial, hepatoprotective, immunomodulatory, antioxidant, and anticancer p …
Among the known natural triterpenoids, we can distinguish lupane-, oleanane-, and ursane-types. Pentacyclic triterpenoids are known t …
Pentacyclic Triterpenoid Phytochemicals with Anticancer Activity: Updated Studies on Mechanisms and Targeted Delivery.
Nistor M, Rugina D, Diaconeasa Z, Socaciu C, Socaciu MA. Nistor M, et al. Int J Mol Sci. 2023 Aug 18;24(16):12923. doi: 10.3390/ijms241612923. Int J Mol Sci. 2023. PMID: 37629103 Free PMC article. Review.
Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting properties and pharmacological effects, with some representatives, such as betulinic acid (BA) and betulin (B), being mainly investigated as potential anticancer molecules. ...
Pentacyclic triterpenoids (TTs) represent a unique family of phytochemicals with interesting properties and pharmacological effects, …
Pentacyclic and Hexacyclic Osmaarynes and Their Derivatives.
Fei Yang X, Zhang MX, Bin Fu D, Wang Y, Yin J, Hua Liu S. Fei Yang X, et al. Chemistry. 2022 Dec 27;28(72):e202202334. doi: 10.1002/chem.202202334. Epub 2022 Nov 15. Chemistry. 2022. PMID: 36198664
Although osmabenzyne, osmanaphthalyne, osmaphenanthryne, and osmaanthracyne have been previously reported, the synthesis of polycyclic osmaarynes is still a challenge. Herein, we report the successful synthesis of the first pentacyclic osmaarynes (pyreno[b]osmabenzynes 1 a …
Although osmabenzyne, osmanaphthalyne, osmaphenanthryne, and osmaanthracyne have been previously reported, the synthesis of polycyclic osmaa …
The Potential Application of Pentacyclic Triterpenoids in the Prevention and Treatment of Retinal Diseases.
Cheng Z, Li Y, Zhu X, Wang K, Ali Y, Shu W, Zhang T, Zhu L, Murray M, Zhou F. Cheng Z, et al. Planta Med. 2021 Jun;87(7):511-527. doi: 10.1055/a-1377-2596. Epub 2021 Mar 24. Planta Med. 2021. PMID: 33761574 Free article. Review.
Pentacyclic triterpenoids have great potential in preventing and/or treating retinal pathologies. ...This review summarizes recent in vitro and in vivo evidence for the pharmacological potential of pentacyclic triterpenoids in the prevention and treatment of retinal …
Pentacyclic triterpenoids have great potential in preventing and/or treating retinal pathologies. ...This review summarizes recent in …
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